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Its success has spawned an immense interest in using the hosts’ immune system in selectively targeting tumor cells by attacking tumor-specific surface antigens.

These surface epitopes represent ideal targets as they allow effective anticancer therapy while relatively sparing normal tissues.m Abs represent the cornerstone of passive immunotherapy, which involves engineering of B or T cell receptors targeting a desired antigen and infusion into patients with disease.

Pugnet G, Pagnoux C, Terrier B, Perrodeau E, Puéchal X, Karras A, Khouatra C, Aumaître O, Cohen P, Maurier F, Decaux O, Ninet J, Gobert P, Quemeneur T, Blanchard-Delaunay C, Godmer P, Carron PL, Hatron PY, Limal N, Hamidou M, Ducret M, Daugas E, Papo T, , Chatelet V, Moulin B, Freguin C, Hazzan M, Lang P, Legendre C, Merville P, Mourad G, Mousson C, Pouteil-Noble C, Purgus R, Rerolle JP, Sayegh J, Westeel PF, Zaoui P, Boivin H, Le Gouge A, Lebranchu Y.

Styczynski J, Tridello G, Gil L, Ljungman P, Hoek J, Iacobelli S, Ward KN, Cordonnier C, Einsele H, Socie G, Milpied N, Veelken H, Chevallier P, Yakoub-Agha I, Maertens J, Blaise D, Cornelissen J, Michallet M, Impact of Donor Epstein-Barr Virus Serostatus on the Incidence of Graft-Versus-Host Disease in Patients With Acute Leukemia After Hematopoietic Stem-Cell Transplantation: A Study From the Acute Leukemia and Infectious Diseases Working Parties of the European Society for Blood and Marrow Transplantation.

Expression of PD-L1 on malignant or stromal cells in the tumor environment for example leads to T-cell anergy.

Its main function is to activate B-cells, allowing proliferation and differentiation.Option mosaic_size tells how many slots should be in mosaic., de Boysson H, Espitia O, Fau G, Fauchais AL, Galateau-Sallé F, Haroche J, Héron E, Lapébie FX, Liozon E, Luong Nguyen LB, Magnant J, Manrique A, Matt M, de Menthon M, Mouthon L, Puéchal X, Pugnet G, Quemeneur T, Régent A, Saadoun D, , Sène D, Smets P, Yelnik C, Sailler L, Mahr A; “Groupe d’étude français des artérites des gros vaisseaux (GEFA)”, under the aegis of the “Filière des maladies auto-immunes et auto-inflammatoires rares (FAI(2)R)”.After specifying pseudo-url mosaic:// you need to enter stream names separated by comma.

Option size reduces size of each stream in mosaic to this size.

Many of these agents have already demonstrated significant activity in clinical trials.



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